Which side effect described as 'cant shit' is associated with tricyclic antidepressants?

Which side effect described as 'cant shit' is associated with tricyclic antidepressants?

• A. Photophobia/blurred vision
• B. Urinary retention
• C. Dry mouth
• D. Constipation

Answer: (D)

Tricyclic antidepressants cause anticholinergic effects by blocking muscarinic receptors, which slows down the gut and reduces secretions. That reduction in GI motility leads to constipation, so the slang phrase “cant shit” aligns with this side effect. While other anticholinergic effects like dry mouth, blurred vision, and urinary retention can also occur with TCAs, constipation is the symptom that directly reflects slowed bowel movement. In practice, this means being cautious in patients prone to constipation or with limited bowel function, and addressing it with hydration, fiber, activity, or appropriate laxatives if needed.

Tricyclic antidepressants cause anticholinergic effects by blocking muscarinic receptors, which slows down the gut and reduces secretions. That reduction in GI motility leads to constipation, so the slang phrase “cant shit” aligns with this side effect. While other anticholinergic effects like dry mouth, blurred vision, and urinary retention can also occur with TCAs, constipation is the symptom that directly reflects slowed bowel movement. In practice, this means being cautious in patients prone to constipation or with limited bowel function, and addressing it with hydration, fiber, activity, or appropriate laxatives if needed.